Aspirin

Aspirin Uses

Aspirin is used for Pain, Fever

How Aspirin Works

Aspirin works to prevent the platelets in your blood from clumping and clotting in your arteries, thereby reducing these risks by improving blood flow to your heart and brain.

Common side effects of Aspirin

Diarrhoea, Constipation, Nausea, Vomiting, Stomach pain, Hearing problems, Abdominal Pain

Interaction

Drug ACE inhibitors: May decrease antihypertensive effects. Monitor BP closely.

Acetazolamide: May cause accumulation and toxicity of acetazolamide, resulting in CNS depression, metabolic acidosis, anorexia, and death. Administer together with caution and monitor patient for toxicity.

Ammonium chloride and other urine acidifiers: May increase levels of aspirin products. Watch for aspirin toxicity.

Antacids in high doses and other urine alkalinizers: May decrease levels of aspirin products. Watch for decreased aspirin effect.

Anticoagulants, antiplatelet agents: May increase risk of bleeding. Use with extreme caution if these drugs must be used together.

Beta blockers: May decrease antihypertensive effect. Avoid long-term aspirin use if patient is taking antihypertensives.

Corticosteroids: May enhance salicylate elimination and decrease drug level. Watch for decreased aspirin effect.

Diuretics: May decrease effectiveness of diuretics in patients with underlying renal or CV disease. Monitor patient for effectiveness.

Heparin: May increase risk of bleeding. Monitor coagulation studies and patient closely if used together.

Ibuprofen, other NSAIDs: May negate the antiplatelet effect of low-dose aspirin therapy. Patients using immediate-release aspirin (not enteric-coated) should take ibuprofen at least 30 minutes after or more than 8 hours before aspirin. Occasional use of ibuprofen is unlikely to have a negative effect.

Influenza virus vaccine, live: Increased risk of Reye syndrome. Use together is contraindicated in children and adolescents.

Methotrexate: May increase risk of methotrexate toxicity. Avoid using together.

Oral antidiabetics: May increase hypoglycemic effect. Monitor patient closely.

Probenecid, sulfinpyrazone: May decrease uricosuric effect. Avoid using together.

Valproic acid: May increase valproic acid level. Avoid using together.

Herb White willow: Contains salicylates and may increase risk of adverse effects. Discourage use together.

Food Caffeine: May increase drug absorption. Watch for increased effects.

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