Carvedilol

Carvedilol Uses

Carvedilol is used for Hypertension, Heart Failure

How Carvedilol Works

Carvedilol reduces cardiac output and tachycardia, causes vasodilation, and decreases peripheral vascular resistance, which reduces blood pressure and cardiac workload. When given for at least 4 weeks, carvedilol reduces plasma renin activity.

Common side effects of Carvedilol

Depression, Dizziness, Fatigue, Fever, Headache, Abdominal Pain, Diarrhea, Nausea, Vomiting

Interaction

Drug : amiodarone; other CYP2C9 drugs, such as fluconazole: Increased risk of bradycardia or heart block.

beta blockers, digoxin: Increased risk of bradycardia.

calcium channel blockers especially diltiazem and verapamil: Abnormal cardiac conduction and, possibly, increased adverse effects of calcium channel blockers .

catecholamine-depleting drugs such as reserpine, MAO inhibitors: Additive effects, increased risk of hypotension and bradycardia.

cimetidine: Increased blood carvedilol level.

clonidine: Risk of tachycardia and hypertension when clonidine is discontinued.

cyclosporine, digoxin: Increased blood levels of these drugs.

digoxin: Possibly increased digoxin level.

oral antidiabetics: Increased risk of hypoglycemia.

rifampin: Decreased blood carvedilol level.

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