Diclofenac

Diclofenac Uses

Diclofenac is used for Pain Relief, Rheumatoid Arthritis

How Diclofenac Works

Diclofenac works by blocking the action of a substance in the body called cyclo-oxygenase (COX), Diclofenac blocks the production of these prostaglandins and this reduces inflammation and pain.

Common side effects of Diclofenac

Nausea, Vomiting, Dizziness, Dry Mouth, Altered Taste, Abdominal Pain, Agitation, Anxiety, Fever, Constipation, Allergic Reaction, Impaired Concentration, Sweating, Headache

Interaction

Drug : acetaminophen: Increased risk of adverse renal effects with long-term concurrent use.

anticoagulants, thrombolytics: Prolonged PT, increased risk of bleeding.

antihypertensives: Decreased antihypertensive effectiveness.

aspirin, other NSAIDs, salicylates: Increased GI irritability and bleeding, decreased diclofenac effectiveness.

beta blockers: Impaired antihypertensive effect.

cefamandole, cefoperazone, cefotetan, plicamycin, valproic acid: Increased risk of hypoprothrombinemia.

cimetidine: Altered blood diclofenac level.

colchicine, corticotropin long-term use, glucocorticoids, potassium supplements:Increased GI irritability and bleeding.

cyclosporine, gold compounds, nephrotoxic drugs: Increased risk of nephrotoxicity.

digoxin: Increased blood digoxin level.

insulin, oral antidiabetics: Decreased effects of these drugs.

lithium: Increased risk of lithium toxicity.

loop diuretics: Decreased diuretic effects.

methotrexate: Increased risk of methotrexate toxicity.

phenytoin: Increased blood phenytoin level potassium-sparing diuretics: Increased risk of hyperkalemia.

probenecid: Increased diclofenac toxicity.

Food : food: Delayed absorption of delayed-release tablets.

Activity : alcohol use: Increased risk of GI irritability and bleeding.

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