Mycophenolate mofetil

Mycophenolate mofetil Uses

Mycophenolate mofetil is used for Prevents Organ Rejection

How Mycophenolate mofetil Works

Mycophenolate mofetil inhibits proliferative response of T and B lymphocytes, suppresses antibody formation by B lymphocytes, and may inhibit recruitment of leukocytes into sites of inflammation and graft rejection.

Common side effects of Mycophenolate mofetil

Asthenia, Fever, Chest Pain, Edema, Hypertension, Dizziness, Hypokalemia, Hypotension, Tachycardia, Headache, Pain, Tremor, Hypophosphatemia, Acne, Rash, Alopecia

Interaction

Drug Acyclovir, ganciclovir, other drugs that undergo renal tubular secretion: May increase risk of toxicity for both drugs. Monitor patient closely.

Antacids with magnesium and aluminum hydroxides: May decrease mycophenolate absorption. Separate dosing times.

Azathioprine: May increase risk of bone marrow suppression. Don't use together.

Cholestyramine: May interfere with enterohepatic recirculation, reducing mycophenolate bioavailability. Avoid using together.

Cyclosporine, drugs that alter normal GI flora, rifamycins (rifampin): May decrease mycophenolate level. Monitor response to therapy and increase dosage if necessary.

Hormonal contraceptives: May decrease effectiveness of contraceptive. Recommend addition of barrier form of contraception during treatment and for 6 weeks after treatment ends.

Immunosuppressants (sirolimus, tacrolimus): May increase mycophenolate level. Monitor patient closely.

Live-virus vaccines: May decrease vaccine effectiveness. Avoid using together.

Phenytoin, theophylline: May increase both drug levels. Monitor drug levels closely.

Probenecid, salicylates: May increase mycophenolate level. Monitor patient closely.

Herb Cat's claw, echinacea: May increase immunostimulation. Discourage use together.

Food Any food: May delay absorption of extended-release form. Advise patient to take on an empty stomach 1 hour before or 2 hours after a meal.

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