Nebivolol

Nebivolol Uses

Nebivolol is used for Hypertension

How Nebivolol Works

Nebivolol selectively blocks beta-adrenergic receptors, reducing HR, myocardial contractility, and 1 sympathetic tone. Nebivolol also reduces BP by suppressing renin activity and decreasing peripheral vascular resistance.

Common side effects of Nebivolol

Asthenia, Dizziness, Nausea, Fatigue, Headache, Insomnia, Hypercholesterolemia, Hyperuricemia, Chest Pain, Peripheral Edema, Dyspnea, Paresthesia, Bradycardia, Abdominal Pain, Diarrhea, Rash

Interaction

Drug :Alpha blockers: May enhance severity and duration of hypotension. A smaller starting 1 dose of alpha blocker may be necessary.

1 Antidiabetic agents (insulin, sulfonylureas): May mask signs of hypoglycemia. Monitor blood glucose level.

Beta agonists (dobutamine, isoproterenol): May reverse nebivolol effects or cause protracted, severe hypotension. Avoid concomitant use.

Beta blockers (atenolol, nadolol): May increase synergistic activity and bradycardia. Don't use together.

Catecholamine-depleting drugs (such as guanethidine, reserpine): May cause bradycardia or severe hypotension. Monitor patient closely.

Clonidine: May cause further decrease in BP. Simultaneous withdrawal may cause life-threatening rebound hypertension. Discontinue nebivolol for several days before gradual tapering of clonidine.

CYP2D6 inhibitors (fluoxetine, paroxetine, propafenone, quinidine): May increase nebivolol level. Monitor BP closely, and adjust nebivolol dose as needed.

Digoxin, diltiazem, disopyramide, verapamil: May increase the risk of bradycardia. Monitor patient's ECG and vital signs.

Fingolimod: May increase risk of bradycardia. Monitor patient closely.

Mefloquine: May cause CV toxicity. Consider an alternative drug.

NSAIDs: May decrease antihypertensive effect. Monitor BP; adjust nebivolol dosage as needed.

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