Olanzapine

Olanzapine Uses

Olanzapine is used for Schizophrenia, Bipolar Disorder (Manic Depression)

How Olanzapine Works

Olanzapine may achieve antipsychotic effects by antagonizing dopamine and serotonin receptors. Anticholinergic effects may result from competitive binding to and antago-nism of the muscarinic receptors M1 through M5.

Common side effects of Olanzapine

Dizziness, Drowsiness, Fatigue, Headache, Insomnia, Constipation, Diarrhea, Nausea, Vomiting

Interaction

Drug : anticholinergics: Increased anticholinergic effects, altered thermoregulation.

antihypertensives: Increased effects of both drugs, increased risk of hypotension.

benzodiazepines parenteral: Increased risk of excessive sedation and cardiorespiratory depression.

carbamazepine, omeprazole, rifampin: Increased olanzapine clearance.

CNS depressants: Additive CNS depression, potentiated orthostatic hypotension.

diazepam: Increased CNS depressant effects.

fluvoxamine: Decreased olanzapine clearance.

levodopa: Decreased levodopa efficacy.

lorazepam parenteral: Possibly increased somnolence with I.M. olanzapine injection.

Activity : alcohol use: Additive CNS depression, potentiated orthostatic hypotension.

smoking: Decreased blood olanzapine level.

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