Paracetamol

Paracetamol Uses

Paracetamol is used for Mild Pain or Fever, Mild to Moderate Pain, Mild to Moderate Pain with Adjunctive Opioid Analgesics

How Paracetamol Works

Paracetamol thought to produce analgesia by inhibiting prostaglandin and other substances that sensitize pain receptors. Drug may relieve fever through central action in the hypothalamic heat-regulating center.

Common side effects of Paracetamol

Sweating, Headache, Vomiting, Nausea

Interaction

Drug :Barbiturates, carbamazepine, hydantoins, rifampin, sulfinpyrazone: High doses or long-term use of these drugs may reduce therapeutic effects and enhance hepatotoxic effects of acetaminophen. Avoid using together.

Busulfan: May increase busulfan level. Monitor patient closely.

Cholestyramine resin: May decrease acetaminophen absorption. Give at least 1 hour after acetaminophen or consider therapy change.

Sorafenib: May increase levels of both drugs. Avoid use together.

Warfarin: May increase hypoprothrombinemic effects with long-term use with high doses of acetaminophen. Monitor INR closely.

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