Paroxetine

Paroxetine Uses

Paroxetine is used for Depression, Obsessive Compulsive Disorder, Anxiety Disorder, Premenstrual Dysphoric Disorder

How Paroxetine Works

Paroxetine works by preventing the reuptake of one neurotransmitter, serotonin, by nerve cells after it has been released.

Common side effects of Paroxetine

Fatigue, Headache, Insomnia, Lethargy, Constipation, Diarrhea, Ejaculation Disorder, Nausea, Vomiting

Interaction

Drug : antacids: Hastened release of C.R. paroxetine aspirin, NSAIDs, warfarin: Increased anticoagulant activity and risk of bleeding.

astemizole: Increased risk of arrhythmias.

atomoxetine; risperidone; other drugs metabolized by CYP2D6, such as amitriptyline, desipramine, fluoxetine, imipramine, phenothiazines, tamoxifen, type IC antiarrhythmics: Increased plasma levels of these drugs.

barbiturates, primidone: Decreased blood paroxetine level.

cimetidine: Possibly increased blood paroxetine level.

cisapride, isoniazid, MAO inhibitors, procarbazine: Possibly serotonin syndrome.

codeine, haloperidol, metoprolol, perphenazine, propranolol, risperidone, thioridazine: Decreased metabolism and increased effects of these drugs.

cyproheptadine: Decreased paroxetine effects.

dextromethorphan: Decreased dextromethorphan metabolism and increased risk of toxicity.

digoxin: Possibly decreased digoxin effects.

encainide, flecainide, propafenone, quinidine: Potentiated toxicity of these drugs.

fosamprenavir, ritonavir: Decreased plasma paroxetine level.

lithium: Possibly increased blood paroxetine level, increased risk of serotonin syndrome.

methadone: Decreased methadone metabolism, increased risk of adverse effects.

phenytoin: Possibly phenytoin toxicity.

pimozide: Increased risk of prolonged QT interval.

procyclidine: Increased blood procyclidine level and anticholinergic effects.

serotonergic drugs such as linezolid, St. John's wort, tramadol, triptans, and tryptophan: Increased risk of serotonin syndrome.

tamoxifen: Decreased tamoxifen effectiveness.

theophylline: Possibly increased blood theophylline level and risk of toxicity.

thioridazine: Increased thioridazine level, possibly leading to prolonged QT interval and life-threatening ventricular arrhythmias.

tramadol: Increased risk of serotonin syndrome and seizures.

tricyclic antidepressants: Increased metabolism and blood antidepressant levels; increased risk of toxicity, including seizures.

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