Propranolol

Propranolol Uses

Propranolol is used for Hypertension, Angina, Blood Pressure, Irregular Heartbeats

How Propranolol Works

Propranolol works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure.

Common side effects of Propranolol

Anxiety, Depression, Dizziness, Drowsiness, Fatigue, Fever, Insomnia, Lethargy, Nervousness, Weakness, Abdominal Pain, Constipation, Diarrhea, Nausea, Vomiting
Bronchospasm, Dyspnea, Respiratory Distress, Wheezing

Interaction

Drug : ACE inhibitors: Increased risk of hypotension, especially in presence of acute MI.

allergen immunotherapy, allergenic extracts for skin testing: Increased risk of serious systemic adverse reactions or anaphylaxis.

amiodarone: Additive depressant effects on.

conduction, negative inotropic effects anesthetics hydrocarbon inhalation:Increased risk of myocardial depression and hypotension beta blockers: Additive beta blockade effects.

bupivacaine, lidocaine, mepivacaine: Decreased clearance of these drugs, possibly increased risk of toxicity calcium channel blockers, clonidine, diazoxide, guanabenz, resperpine, other hypotension-producing drugs: Additive hypotensive effect and, possibly, other beta blockade effects.

catecholamine-depleting drugs, such as reserpine: Increased risk of hypotension, bradycardia, vertigo, syncope, and orthostatic hypotension.

cimetidine: Possibly interference with propranolol clearance.

digitalis glycosides: Increased risk of bradycardia.

diltiazem: Increased risk of bradycardia, hypotension, high-degree heart block, and heart failure.

dobutamine, isoproterenol: Reversed effects of propranolol.

doxazosin, terazosin: Increased risk of orthostatic hypotension.

epinephrine: Increased risk of uncontrolled hypertension.

estrogens: Decreased antihypertensive effect of propranolol.

fentanyl, fentanyl derivatives: Possibly increased risk of initial bradycardia after induction doses of fentanyl or a derivative with long-term propranolol use.

glucagon: Possibly blunted hyperglycemic response.

insulin, oral antidiabetic drugs: Possibly impaired glucose control, masking of tachycardia in response to hypoglycemia.

MAO inhibitors, tricyclic antidepressants: Increased risk of significant hypertension.

neuroleptic drugs: Increased risk of hypotension and cardiac arrest.

neuromuscular blockers: Possibly potentiated and prolonged action of these drugs.

NSAIDs: Possibly decreased hypotensive effects.

phenothiazines: Increased blood levels of both drugs.

phenytoin: Additive cardiac depressant effects with parenteral phenytoin.

prazosin: Increased risk of first-dose hypotension.

propafenone: Increased blood level and half life of propranolol.

quinidine: Increased propranolol level, resulting in higher degrees of beta blockade and orthostatic hypotension.

sympathomimetics, xanthines: Possibly mutual inhibition of therapeutic effects.

thyroxine: Possibly decreased T3 level.

verapamil: Increased risk of bradycardia, heart failure, and cardiovascular collapse.

warfarin: Increased risk of bleeding.

Activity : alcohol: Possibly increased plasma propranolol level.

nicotine chewing gum, smoking cessation, smoking deterrents: Increased therapeutic effects of propranolol.

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