Tacrolimus

Tacrolimus Uses

Tacrolimus is used for To Prevent Organ Rejection in Patients (Liver, Kidney, or Heart Transplantation), Eczema

How Tacrolimus Works

Tacrolimus works on the immune system and directly on skin cells.

Common side effects of Tacrolimus

Fever, Dizziness, Headache, Insomnia, Constipation, Diarrhea, Nausea, Vomiting, Renal Dysfunction

Interaction

Drug : Increased risk of renal impairment : aminoglycosides, amphotericin B, cisplatin, cyclosporine, other nephrotoxic drugs.

bromocriptine, chloramphenicol, cimetidine, cisapride, clarithromycin, clotrimazole, cyclosporine, danazol, diltiazem, erythromycin, ethinyl estradiol, fluconazole, ganciclovir, itraconazole, ketoconazole, lansoprazole, magnesium-aluminum-hydroxide, metoclopramide, methylprednisolone, nefazodone, nicardipine, nifedipine, nelfinavir, omeprazole, protease inhibitors, ritonavir, troleandomycin, verapamil, voriconazole: Possibly increased blood tacrolimus level.

carbamazepine, caspofungin, phenobarbital, phenytoin, rifabutin, rifampin, sirolimus, St. John's wort: Possibly decreased blood tacrolimus level.

mycophenolic acid: Possibly increased plasma mycophenolic acid level.

phenytoin: Possibly increased blood phenytoin level.

sirolimus: Increased risk of wound healing complications, renal dysfunction, and insulin-dependent post-transplant diabetes mellitus.

vaccines live or killed: Possibly suppressed immune response and increased adverse effects of vaccine.

Food : grapefruit juice: Possibly increased blood tacrolimus trough levels in liver transplant patients.

high-fat foods: Decreased absorption of oral tacrolimus.

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