Interaction Drug : Increased risk of renal impairment : aminoglycosides, amphotericin B, cisplatin, cyclosporine, other nephrotoxic drugs.
bromocriptine, chloramphenicol, cimetidine, cisapride, clarithromycin, clotrimazole, cyclosporine, danazol, diltiazem, erythromycin, ethinyl estradiol, fluconazole, ganciclovir, itraconazole, ketoconazole, lansoprazole, magnesium-aluminum-hydroxide, metoclopramide, methylprednisolone, nefazodone, nicardipine, nifedipine, nelfinavir, omeprazole, protease inhibitors, ritonavir, troleandomycin, verapamil, voriconazole: Possibly increased blood tacrolimus level.
carbamazepine, caspofungin, phenobarbital, phenytoin, rifabutin, rifampin, sirolimus, St. John's wort: Possibly decreased blood tacrolimus level.
mycophenolic acid: Possibly increased plasma mycophenolic acid level.
phenytoin: Possibly increased blood phenytoin level.
sirolimus: Increased risk of wound healing complications, renal dysfunction, and insulin-dependent post-transplant diabetes mellitus.
vaccines live or killed: Possibly suppressed immune response and increased adverse effects of vaccine.
Food : grapefruit juice: Possibly increased blood tacrolimus trough levels in liver transplant patients.
high-fat foods: Decreased absorption of oral tacrolimus.