Tizanidine Uses

Tizanidine is used for Manage Acute and Intermittent Increases of Muscle Tone with Spasticity

How Tizanidine Works

Tizanidine reduces spasticity by decreasing the release of excitatory amino acids. This alpha 2-adrenergic agonist’s action increases presynaptic inhibition of spinal motor neurons, with the greatest effects on polysynaptic pathways.

Common side effects of Tizanidine

Dyskinesia, Fatigue, Fever, Hallucinations, Slurred Speech, Dry Mouth, Abdominal Pain, Anorexia, Constipation, Diarrhea, Dyspepsia, Nausea, Vomiting


Drug : acetaminophen: Delayed peak effects of acetaminophen.

alpha2-adrenergic agonists: Possibly significant hypotension.

antihypertensives: Additive hypotensive effects.

CYP1A2 inhibitors such as acyclovir, amiodarone, cimetidine, famotidine, mexiletine, propafenone, ticlopidine, verapamil, zileuton, fluroquinolones including ciprofloxacin, fluvoxamine: Possibly increased plasma tizanidine level; increased risk of hypotension and sedation.

oral contraceptives: Decreased tizanidine clearance.

rofecoxib: Possibly increased adverse reactions.

Activity : alcohol use: Increased adverse effects of tizanidine, additive CNS depression.