Uses of Epsolin 100mg Tablet

Epsolin 100mg Tablet is used for the treatment or prevention of the following disease(s):

Tonic-Clonic, Seizures

Side effects of Epsolin 100mg Tablet

Precautions while taking Epsolin 100mg Tablet

Dosage of Epsolin 100mg Tablet

Overdose of Epsolin 100mg Tablet

Onset of Action of Epsolin 100mg Tablet

Duration of Action of Epsolin 100mg Tablet

Precautions & Warnings

Alcohol

Information will be added soon.

Pregnancy

Information will be added soon.

Breastfeeding

Information will be added soon.

Driving

Information will be added soon.

Kidney

Information will be added soon.

Liver

Information will be added soon.

All substitutes for Epsolin 100mg Tablet

For information purpose only. Refer to a healthcare professionals before consuming any medicines and/or drugs.

Interactions

Drug :- acetaminophen: Possibly hepatotoxicity, decreased acetaminophen effects.

activated charcoal, antacids, calcium salts, enteral feedings, sucralfate: Decreased absorption of oral phenytoin.

allopurinol, benzodiazepines, chloramphenicol, cimetidine, disulfiram, fluconazole, isoniazid, itraconazole, methylphenidate, metronidazole, miconazole, omeprazole, phenacemide, ranitidine, sulfonamides, trazodone, trimethoprim: Decreased metabolism and increased effects of phenytoin.

amiodarone, ticlopidine: Possibly increased blood phenytoin level.

antifungals azole: Increased blood phenytoin level, decreased blood antifungal level.

antineoplastics, nitrofurantoin, pyridoxine: Decreased phenytoin effects.

barbiturates: Variable effects on blood phenytoin level.

bupropion, clozapine, loxapine, MAO inhibitors, maprotiline, molindone, phenothiazines, pimozide, thioxanthenes, tricyclic antidepressants: Decreased seizure threshold, decreased anticonvulsant effects.

calcium channel blockers: Increased metabolism and decreased effects of these drugs, possibly increased blood phenytoin level.

carbamazepine: Decreased blood level and effects of carbamazepine, possibly phenytoin toxicity.

carbonic anhydrase inhibitors: Increased riskof osteopenia from phenytoin.

chlordiazepoxide, diazepam: Possibly increased blood phenytoin level, decreased effects of these drugs.

clonazepam: Possibly decreased blood level and effects of clonazepam, possibly phenytoin toxicity.

corticosteroids, cyclosporine, dicumarol, digoxin, disopyramide, doxycycline, estrogens, furosemide, lamotrigine, levodopa, methadone, metyrapone, mexiletine, oral contraceptives, quinidine, sirolimus, tacrolimus, theophylline: Increased metabolism and decreased effects of these drugs.

dopamine: Increased risk of severe hypotension and bradycardia with I.V. phenytoin.

fluoxetine: Increased blood phenytoin level and risk of phenytoin toxicity.

folic acid, leucovorin: Decreased blood phenytoin level, increased risk of seizures.

haloperidol: Decreased effects of haloperidol, decreased anticonvulsant effect of phenytoin.

halothane anesthetics: Increased risk of hepatotoxicity and phenytoin toxicity.

ifosfamide: Decreased phenytoin effects, possibly increased toxicity.

influenza virus vaccine: Possibly decreased phenytoin effects.

insulin, oral antidiabetic drugs: Possibly hyperglycemia, increased blood phenytoin level with tolbutamide.

levonorgestrel, mebendazole, streptozocin, sulfonylureas: Decreased effects of these drugs.

lidocaine, propranolol possibly other beta blockers: Increased cardiac depressant effects with I.V. phenytoin, possibly decreased blood level and increased adverse effects of phenytoin.

lithium: Increased risk of lithium toxicity, increased risk of neurologic symptoms with normal blood lithium level.

meperidine: Increased metabolism and decreased effects of meperidine, possibly meperidine toxicity.

methadone: Possibly increased metabolism of methadone and withdrawal symptoms.

neuromuscular blockers: Shorter duration of action and decreased effects of neuromuscular blockers.

oral anticoagulants: Decreased metabolism and increased effects of phenytoin, early increase and then decrease in anticoagulation.

paroxetine: Decreased bioavailability of both drugs.

phenylbutazone, salicylates: Increased phenytoin effects, possibly phenytoin toxicity primidone: Increased primidone effects, possibly primidone toxicity rifampin: Increased hepatic metabolism of phenytoin.

valproic acid: Possibly decreased phenytoin metabolism, resulting in increased phenytoin effects, possibly decreased blood valproic acid level vitamin D: Possibly decreased vitamin D effects, resulting in rickets or osteomalacia with long-term use of phenytoin.

Activity :- alcohol use: Additive CNS depression, increased phenytoin clearance.

Kunal is a registered pharmacist with RGUHS with over 4 years experience. He is a medicine content contributor at Health-Shoppe.com.