Medically reviewed by Dr. Naresh Dang | Written By Sonu Kumar Rao

Last updated on: November 02, 2020 11:17 am



EPTOIN 50MG INJECTION is used for the treatment or prevention of the following disease(s):

Tonic-Clonic, Seizures

Side effects of EPTOIN 50MG INJECTION

The most common side effects of EPTOIN 50MG INJECTION are – Nausea, Constipation, Diarrhea, Tiredness, Fever, Rash, Itching

These side effects can usually occur in patients. However, these are only indicative and not all patients will experience them.

Precautions while using EPTOIN 50MG INJECTION

Do not use EPTOIN 50MG INJECTION if you are allergic to – Phenytoin

If you have heart disease, liver or kidney disease, drug or alcohol addiction, consult your doctor before using EPTOIN 50MG INJECTION.

If you are allergic to any medicine or food, consult your doctor before using this medicine.

Use this medicine under the supervision of your doctor.

To avoid an adverse reaction, consult your doctor if you are already taking other medicines.


EPTOIN 50MG INJECTION contains – Phenytoin

Phenytoin works by decreasing abnormal electrical activity in the brain.


The dosage of EPTOIN 50MG INJECTION depends on many factors such as the patient age, health, medical condition or history of the patient and many other conditions.

Please use this medicine as prescribed by your doctor.


If you forget to take a dose of EPTOIN 50MG INJECTION, do not take two doses at the same time, there is a risk of overdose.

If you notice any unusual reaction in your body after taking this medicine, contact your doctor immediately or call your local medical emergency number.

Precautions & Warnings


Information will be added soon.


Information will be added soon.


Information will be added soon.


Information will be added soon.


Information will be added soon.


Information will be added soon.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.

Epsolin 50mg Tablet  ( Zydus Cadila )

158.52  100 Tablets Bottle Tablets Strip


Drug :- acetaminophen: Possibly hepatotoxicity, decreased acetaminophen effects.

activated charcoal, antacids, calcium salts, enteral feedings, sucralfate: Decreased absorption of oral phenytoin.

allopurinol, benzodiazepines, chloramphenicol, cimetidine, disulfiram, fluconazole, isoniazid, itraconazole, methylphenidate, metronidazole, miconazole, omeprazole, phenacemide, ranitidine, sulfonamides, trazodone, trimethoprim: Decreased metabolism and increased effects of phenytoin.

amiodarone, ticlopidine: Possibly increased blood phenytoin level.

antifungals azole: Increased blood phenytoin level, decreased blood antifungal level.

antineoplastics, nitrofurantoin, pyridoxine: Decreased phenytoin effects.

barbiturates: Variable effects on blood phenytoin level.

bupropion, clozapine, loxapine, MAO inhibitors, maprotiline, molindone, phenothiazines, pimozide, thioxanthenes, tricyclic antidepressants: Decreased seizure threshold, decreased anticonvulsant effects.

calcium channel blockers: Increased metabolism and decreased effects of these drugs, possibly increased blood phenytoin level.

carbamazepine: Decreased blood level and effects of carbamazepine, possibly phenytoin toxicity.

carbonic anhydrase inhibitors: Increased riskof osteopenia from phenytoin.

chlordiazepoxide, diazepam: Possibly increased blood phenytoin level, decreased effects of these drugs.

clonazepam: Possibly decreased blood level and effects of clonazepam, possibly phenytoin toxicity.

corticosteroids, cyclosporine, dicumarol, digoxin, disopyramide, doxycycline, estrogens, furosemide, lamotrigine, levodopa, methadone, metyrapone, mexiletine, oral contraceptives, quinidine, sirolimus, tacrolimus, theophylline: Increased metabolism and decreased effects of these drugs.

dopamine: Increased risk of severe hypotension and bradycardia with I.V. phenytoin.

fluoxetine: Increased blood phenytoin level and risk of phenytoin toxicity.

folic acid, leucovorin: Decreased blood phenytoin level, increased risk of seizures.

haloperidol: Decreased effects of haloperidol, decreased anticonvulsant effect of phenytoin.

halothane anesthetics: Increased risk of hepatotoxicity and phenytoin toxicity.

ifosfamide: Decreased phenytoin effects, possibly increased toxicity.

influenza virus vaccine: Possibly decreased phenytoin effects.

insulin, oral antidiabetic drugs: Possibly hyperglycemia, increased blood phenytoin level with tolbutamide.

levonorgestrel, mebendazole, streptozocin, sulfonylureas: Decreased effects of these drugs.

lidocaine, propranolol possibly other beta blockers: Increased cardiac depressant effects with I.V. phenytoin, possibly decreased blood level and increased adverse effects of phenytoin.

lithium: Increased risk of lithium toxicity, increased risk of neurologic symptoms with normal blood lithium level.

meperidine: Increased metabolism and decreased effects of meperidine, possibly meperidine toxicity.

methadone: Possibly increased metabolism of methadone and withdrawal symptoms.

neuromuscular blockers: Shorter duration of action and decreased effects of neuromuscular blockers.

oral anticoagulants: Decreased metabolism and increased effects of phenytoin, early increase and then decrease in anticoagulation.

paroxetine: Decreased bioavailability of both drugs.

phenylbutazone, salicylates: Increased phenytoin effects, possibly phenytoin toxicity primidone: Increased primidone effects, possibly primidone toxicity rifampin: Increased hepatic metabolism of phenytoin.

valproic acid: Possibly decreased phenytoin metabolism, resulting in increased phenytoin effects, possibly decreased blood valproic acid level vitamin D: Possibly decreased vitamin D effects, resulting in rickets or osteomalacia with long-term use of phenytoin.

Activity :- alcohol use: Additive CNS depression, increased phenytoin clearance.

About Reviewer

Dr. Naresh Dang is an MD in Internal Medicine. He has special interest in the field of Diabetes, and has over two decades of professional experience in his chosen field of specialty. Dr. Dang is an expert in the managememnt of Diabetes, Hypertension and Lipids. He also provides consultation for Life Style Management.

About Author

Sonu Kumar is a registered pharmacist with Bihar State Pharmacy Council with over 6 months experience. He is a medicine content contributor at Zotezo.