Yohimbine

What is Yohimbine?

Yohimbine is a naturally occurring chemical compound that is derived from the bark of the African yohimbe tree. It has long been used as a traditional herbal remedy in certain African cultures for its alleged aphrodisiac properties. In recent years, yohimbine has gained popularity as a dietary supplement and is often marketed as a fat burner and performance enhancer.

Yohimbine works by blocking alpha-2 adrenergic receptors in the body, which can lead to increased release of norepinephrine, a hormone that plays a role in fat metabolism and energy expenditure. This mechanism of action is believed to contribute to yohimbine’s potential benefits for weight loss and athletic performance.

While yohimbine is available in both prescription and over-the-counter forms, it is important to note that it is not approved by the Food and Drug Administration (FDA) for any specific medical use. Most commonly, it is found in dietary supplements and marketed as a weight loss aid or pre-workout supplement.

What are the benefits of Yohimbine?

Yohimbine, derived from the bark of the yohimbe tree native to Africa, has garnered significant attention in recent years for its potential health benefits, particularly in the realm of weight loss and sexual health.

Weight Loss: Yohimbine is widely recognized for its potential role in promoting weight loss and fat burning. It functions by increasing adrenaline levels in the body, which in turn enhances lipolysis—the breakdown of fats for energy. Studies have suggested that yohimbine may aid in reducing body fat, especially in stubborn areas such as the abdomen and thighs.

Improved Sexual Health: Yohimbine has been historically used as an aphrodisiac and is believed to enhance sexual performance and libido, particularly in men. It works by increasing blood flow to the genitals and may help alleviate symptoms of erectile dysfunction (ED) by stimulating the release of nitric oxide, which relaxes blood vessels and promotes vasodilation.

Potential for Treating Erectile Dysfunction (ED): Yohimbine’s ability to improve blood flow and enhance sexual arousal has led to its exploration as a potential treatment for ED. While research in this area is ongoing, some studies have shown promising results, suggesting that yohimbine may be effective, especially in cases where ED is related to psychological factors rather than physiological issues.

Appetite Suppression: Yohimbine has been implicated in reducing appetite and promoting satiety, which can be beneficial for individuals seeking to control their caloric intake and manage weight.

Enhanced Athletic Performance: Some athletes and fitness enthusiasts use yohimbine as a pre-workout supplement due to its potential to increase energy levels, improve focus, and boost endurance. These effects are attributed to yohimbine’s ability to stimulate the central nervous system and increase adrenaline levels.

What are the Side-effects of Yohimbine?

While yohimbine offers several potential benefits, it is essential to consider its associated side effects, which can vary in severity depending on individual tolerance and dosage. Common side effects of yohimbine supplementation may include:

Increased Heart Rate: Yohimbine can elevate heart rate and blood pressure, especially at higher doses. Individuals with pre-existing cardiovascular conditions should exercise caution when using yohimbine to avoid adverse effects.

Anxiety and Nervousness: Yohimbine’s stimulatory effects on the central nervous system may induce feelings of anxiety, restlessness, and nervousness in some individuals.

Gastrointestinal Distress: Yohimbine supplementation may cause digestive issues such as nausea, bloating, gas, or diarrhea, particularly when taken on an empty stomach.

Sleep Disturbances: Some users may experience difficulty falling asleep or disrupted sleep patterns after taking yohimbine, especially if consumed in the evening or close to bedtime.

Interactions with Medications: Yohimbine can interact with certain medications, including antidepressants, blood pressure medications, and stimulants, potentially exacerbating side effects or interfering with their efficacy.

What are the various types of Yohimbine?

Yohimbine supplements are available in various forms, including:

Yohimbe Bark Extract: Traditionally, yohimbe bark extract was used in herbal preparations and teas for its medicinal properties. However, the concentration of yohimbine in yohimbe bark extract can vary significantly, making dosing less precise.

Yohimbine HCl (Hydrochloride): Yohimbine hydrochloride is a synthetic form of yohimbine that is standardized for potency and purity. It is commonly found in dietary supplements and medications designed to support weight loss and sexual health.

Yohimbine Supplements: Yohimbine is available in various supplemental forms, including capsules, tablets, and liquid extracts, making it convenient for consumption and dosage regulation.

How does Yohimbine work?

The primary mechanism of action of yohimbine revolves around its ability to block alpha-2 adrenergic receptors in the body. By inhibiting these receptors, yohimbine increases the release of norepinephrine and adrenaline, two hormones involved in the body’s stress response and energy regulation. This cascade of events leads to several physiological effects, including:

Increased Lipolysis: Yohimbine promotes the breakdown of stored fats (lipolysis) by activating beta-adrenergic receptors, which stimulate the release of fatty acids from adipose tissue into the bloodstream for energy production.

Enhanced Blood Flow: Yohimbine’s vasodilatory properties help improve blood flow by relaxing smooth muscle tissue in blood vessels, thereby facilitating the delivery of oxygen and nutrients to various tissues and organs, including the genitalia.

Central Nervous System Stimulation: Yohimbine acts as a central nervous system stimulant, increasing alertness, energy levels, and cognitive function by modulating neurotransmitter activity in the brain.

Appetite Regulation: Yohimbine may influence appetite and satiety signals in the brain, potentially reducing food intake and promoting weight loss.

Recommended dosage of Yohimbine

Determining the appropriate dosage of yohimbine is crucial to minimize the risk of adverse effects while maximizing its potential benefits. It is recommended to start with a low dose and gradually increase as tolerated. However, individual responses to yohimbine can vary, so it is essential to consult with a healthcare professional before initiating supplementation.

Weight Loss: For weight loss purposes, typical dosages of yohimbine range from 5 to 20 milligrams per day, divided into multiple doses taken with meals. It is advisable to avoid taking yohimbine close to bedtime to prevent sleep disturbances.

Sexual Health: In the context of sexual health and erectile dysfunction, yohimbine dosages may vary depending on individual needs and response. A common starting dose is around 5.4 milligrams three times daily, although higher doses may be required for optimal efficacy.

Precautions: Individuals with pre-existing medical conditions, such as hypertension, heart disease, anxiety disorders, or gastrointestinal issues, should exercise caution when using yohimbine. Pregnant or breastfeeding women should avoid yohimbine supplementation due to potential risks to fetal and infant health.

Natural and Food Sources of Yohimbine

As a dietitian, I often receive inquiries about natural sources of yohimbine and its various food sources. Yohimbine is a compound found in the bark of the Pausinystalia yohimbe tree, primarily indigenous to Africa. It has gained popularity for its potential benefits in weight loss, improving sexual dysfunction, and promoting general well-being. While yohimbine supplements are available, getting it naturally from food sources is always preferable.

Pausinystalia Yohimbe Bark

The most direct source of yohimbine is the bark of the Pausinystalia yohimbe tree. This is where the compound was originally discovered and is still commonly used in traditional medicine in certain cultures. However, it is vital to proceed with caution when using the bark as it requires careful preparation due to its high concentrations of yohimbine. Improper extraction may lead to unnecessary health risks.

Dark Chocolate

Yes, you read that correctly! Dark chocolate, particularly varieties containing at least 70% cocoa, is an excellent natural source of yohimbine. This compound is present in small amounts, but can still provide some of the benefits associated with its consumption. Besides yohimbine, dark chocolate is also a rich source of antioxidants, minerals, and healthy fats. So, enjoy a small piece of dark chocolate guilt-free for a potential yohimbine boost!

Meat and Fish

Meat lovers, rejoice! Yohimbine can also be found in meat, particularly in lean cuts of beef. Bison, lamb, and venison are other good options. When it comes to fish, it is primarily found in tuna. These sources offer the added advantages of high-quality protein, essential amino acids, and various other vitamins and minerals. However, it is important to note that the amounts of yohimbine in these foods are relatively low, so they should not be solely relied upon for its supplementation.

Frequently Asked Question on Yohimbine

What is Yohimbine?

Yohimbine is a naturally occurring compound found in the bark of the Pausinystalia yohimbe tree. It has been used for centuries in traditional medicine to enhance sexual performance and as an aphrodisiac. Yohimbine is also known for its fat-burning properties and is often used as a weight loss supplement.

How does Yohimbine work?

Yohimbine works by blocking the alpha-2 adrenergic receptors in the body. This action leads to increased adrenaline levels, which can boost energy expenditure and fat oxidation. Yohimbine has also been found to improve blood flow, particularly to areas such as the genitals, which is why it is often used to address erectile dysfunction.

Is Yohimbine safe?

When used as directed and in appropriate dosages, Yohimbine is generally considered safe for most people. However, it is important to note that individual tolerances to Yohimbine can vary, and some users may experience side effects such as increased heart rate, anxiety, gastrointestinal distress, high blood pressure, or dizziness. It is always advisable to consult with a healthcare professional before starting any new supplement, especially if you have underlying health conditions or are taking medications.

Can Yohimbine help with weight loss?

Yohimbine is often used as a weight loss supplement due to its ability to increase energy expenditure and fat oxidation. However, it is important to note that while Yohimbine may have some benefits in promoting weight loss, it is not a magic solution and should be used in conjunction with a balanced diet and regular exercise. Additionally, individual results may vary, and it is always recommended to consult with a healthcare professional before starting any weight loss regimen.

Can Yohimbine be used to treat erectile dysfunction?

Yohimbine has been found to have a positive impact on sexual function and has been used to address symptoms of erectile dysfunction. It works by improving blood flow, specifically to the genitals, which can help with achieving and maintaining erections. However, it is important to note that the effectiveness of Yohimbine in treating erectile dysfunction can vary among individuals, and it may not be suitable for everyone. If you are experiencing erectile dysfunction, it is recommended to speak with a healthcare professional to determine the underlying cause and appropriate treatment options.

Is Yohimbine legal?

In many countries, including the United States and Canada, Yohimbine is legal and can be purchased as a dietary supplement. However, it is important to be aware of the laws and regulations regarding Yohimbine in your specific location, as they can vary. Always purchase Yohimbine from reputable sources and ensure that the product meets quality standards.

Can Yohimbine be used by women?

While Yohimbine is commonly used by men, it can also be used by women. However, it is important to note that the effects and benefits of Yohimbine may differ among individuals. Women who are pregnant or breastfeeding, or have underlying medical conditions, should consult with a healthcare professional before using Yohimbine or any other dietary supplement.

Dr. Heather Smith

MD, FRCP

Medical Practitioner

By day I’m a critical care physician and medical leader. By night I’m the mom of 2 chaotic, wonderful boys. Somewhere in the middle of all that, I’m building a skincare brand and trying to save the world from plastic waste.