Introduction
Welcome to the world of supplements where we often find ourselves navigating through a jungle of promises and possibilities. In this intriguing landscape, Nicotinamide Riboside (NR) emerges as a captivating compound, garnering attention for its potential health benefits. As a dietitian and author, I invite you to delve into the science, the hype, and the reality surrounding NR supplements.
Nicotinamide Riboside, a form of vitamin B3, has recently captured the spotlight due to its role in cellular energy metabolism and potential anti-aging effects. As we age, our cells experience a decline in NAD+ levels, a coenzyme vital for various biological processes including DNA repair and energy production. NR, by boosting NAD+ levels, has garnered interest for its purported ability to support cellular health and potentially mitigate age-related decline.
In this article, we’ll explore the origins of NR, its mechanisms of action, and the scientific evidence behind its touted benefits. We’ll also address important considerations such as safety, dosage, and its potential interactions with medications or existing health conditions.
Our pick of the 6 best Nicotinamide Riboside Supplements of 2024 in USA
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Let's take a deep dive into these 6 best Nicotinamide Riboside Supplements in USA
Best Overall Nicotinamide Riboside Supplements in USA
PacificCoast NutriLabs
A+
Zotezo review
The Reus Research NMN Supplement Alternative offers high value with 40 servings per package and a 33% increase in NAD levels. While it boosts energy, supports healthy aging, and enhances focus, results may take time to be noticeable for some users.
Product details
Benefits of Reus Research NMN Supplement ...
Drawbacks
A+
Zotezo review
The Orgabay Liposomal Nicotinamide Riboside 2000 MG with TMG and Pterostilbene offers a high-potency formula that boosts NAD+ levels to support healthy aging. While it is easy to swallow and rapidly absorbed, some users may find the price point higher and the 120-count bottle size may not suit those seeking a smaller quantity option.
Product details
Benefits of Orgabay NR 2000mg with NAD+ Support
Weaknesses
A
Zotezo review
The Liposomal Nicotinamide Riboside Supplement 2000 mg with TMG and Pterostilbene offers a potent dose for maximum absorption, boosting NAD+ levels and supporting cellular energy and age defense. Despite a competitive price, the product may be considered high-priced by some consumers, and its stronger taste could be a drawback for some users.
Product details
Benefits of Liposomal NR Supplement with TMG...
Disadvantages
A
Zotezo review
The 2000 MG Liposomal Nicotinamide Riboside Supplement offers a potent dosage with a liposomal delivery system, TMG, and Pterostilbene for added effectiveness in boosting NAD+ levels and enhancing cellular energy. While some individuals sensitive to high dosages may find it too potent, the softgel format and generous supply in two bottles make it convenient for daily intake for most users.
Product details
Benefits of Liposomal NR Supplement with NAD...
Negatives
Thorne Research
B+
Zotezo review
The THORNE ResveraCel supplement offers comprehensive support for healthy aging by boosting NAD+ production, enhancing cellular energy production, and supporting overall metabolism. However, its expensive price point and limited quantity of 60 capsules per bottle may be drawbacks for some consumers.
Product details
Benefits of Thorne ResveraCel – Cellul...
Cons
ChromaDex
B
Zotezo review
TRU NIAGEN – Patented Nicotinamide Riboside NAD+ Supplement provides a potent formula supporting cellular energy metabolism, tissue repair, and healthy aging of key organs while enhancing vitality and overall well-being. However, some users may find it costly compared to other supplements, and headaches have been reported as a potential side effect.
Product details
Benefits of TRU NIAGEN NAD+ Supplement ̵...
Drawbacks
Tips for choosing the right Nicotinamide Riboside Supplements for you
Navigating the world of supplements can feel like embarking on a labyrinthine journey, especially when exploring the realm of Nicotinamide Riboside (NR) supplements. As a dietitian and author, I understand the importance of making informed choices when it comes to selecting supplements for optimal health. In this comprehensive buyer’s guide, we’ll unravel the intricacies of NR supplements, examining various types, certifications, ingredients, sources, and other pertinent factors to consider before making your purchase.
Types of Nicotinamide Riboside Supplements:
When exploring NR supplements, you’ll encounter different formulations tailored to suit diverse preferences and dietary needs. Capsules, softgels, powders, and liquid formulations are among the most common types available in the market. Each format offers unique advantages, ranging from convenience to enhanced absorption rates. Capsules and softgels are popular choices for their ease of consumption and precise dosage measurements, while powders and liquids offer flexibility in dosage customization and absorption rates.
Certifications and Quality Standards:
Prioritizing quality and safety is paramount when selecting NR supplements. Look for products that adhere to rigorous quality standards and are certified by reputable third-party organizations such as NSF International, USP (United States Pharmacopeia), or ConsumerLab.com. These certifications ensure that the supplements meet stringent criteria for purity, potency, and absence of contaminants.
Ingredients to Look For:
When scrutinizing the ingredient list of NR supplements, prioritize products formulated with high-quality, bioavailable Nicotinamide Riboside. Opt for supplements that contain minimal fillers, additives, or artificial ingredients. Additionally, consider products that incorporate synergistic compounds such as resveratrol or pterostilbene, which may enhance the bioavailability and efficacy of NR.
Avoid Harmful Ingredients:
Exercise caution and vigilance when assessing the ingredient list of NR supplements, steering clear of potentially harmful additives or allergens. Be wary of supplements containing artificial colors, flavors, preservatives, or common allergens such as gluten, soy, or dairy. Additionally, avoid products that contain excessive amounts of fillers or bulking agents, which may compromise the purity and potency of the supplement.
Sources of Nicotinamide Riboside:
Nicotinamide Riboside can be sourced from various natural sources, including dairy products, yeast, and certain vegetables. However, NR supplements are primarily derived from synthetic or bioengineered sources to ensure consistency and purity. When selecting NR supplements, prioritize products sourced from reputable manufacturers known for their commitment to quality and transparency in sourcing and production practices.
Dosage and Usage Guidelines:
Determining the appropriate dosage of NR supplements requires careful consideration of individual factors such as age, health status, and specific health goals. While there is no universally recommended dosage for NR, clinical studies suggest that doses ranging from 100 mg to 1000 mg daily are well-tolerated and may confer health benefits. However, it’s advisable to start with a lower dosage and gradually titrate upwards while monitoring for any adverse effects or interactions with medications.
Consultation with Healthcare Professionals:
Before incorporating NR supplements into your regimen, it’s essential to consult with a qualified healthcare professional, especially if you have pre-existing medical conditions or are taking medications. Your healthcare provider can offer personalized guidance based on your unique health profile, ensuring safe and effective supplementation.
Consideration of Potential Interactions:
Nicotinamide Riboside supplements may interact with certain medications or supplements, necessitating caution and careful monitoring. Consult with your healthcare provider to assess potential interactions with medications such as blood thinners, diabetes medications, or chemotherapy drugs. Additionally, consider potential interactions with other supplements or herbs to avoid adverse effects or diminished efficacy.
Transparency and Accountability:
When evaluating NR supplement brands, prioritize companies that demonstrate transparency and accountability in their sourcing, manufacturing, and quality control practices. Look for brands that provide comprehensive information regarding their sourcing of raw materials, manufacturing processes, and quality assurance measures. Additionally, seek out brands that undergo independent third-party testing to verify the purity, potency, and safety of their products.
Consumer Reviews and Feedback:
Harness the power of consumer reviews and feedback to glean insights into the efficacy and quality of NR supplements. Explore reputable online platforms and forums where consumers share their firsthand experiences and opinions regarding various supplement brands. Pay attention to recurring themes and patterns in consumer feedback, focusing on factors such as product effectiveness, taste, and customer service.
Products listed here are carefully reviewed and tested by our expert authors and reviewers. If you buy through links on this page, we may earn a small commission. Here’s our editorial process.
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Benefits of using Nicotinamide Riboside Supplements
Nicotinamide Riboside (NR) supplements have been generating buzz in health and wellness circles for their potential to support various aspects of health and vitality. As a dietitian and author, I’m eager to explore the intriguing science behind NR supplementation and uncover the potential health benefits it may offer.
Cellular Energy Production:
At the heart of Nicotinamide Riboside’s appeal lies its role in cellular energy metabolism. NR serves as a precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for numerous biochemical reactions within the body, including the conversion of nutrients into cellular energy. As we age, NAD+ levels naturally decline, contributing to age-related declines in cellular function and metabolism. By supplementing with NR, individuals may support optimal NAD+ levels, enhancing cellular energy production and metabolic efficiency.
Mitochondrial Function and Anti-Aging:
Mitochondria, often referred to as the “powerhouses” of the cell, play a pivotal role in energy production and cellular function. Nicotinamide Riboside has been shown to support mitochondrial health and function, thereby potentially mitigating age-related decline and promoting longevity. By bolstering mitochondrial biogenesis and enhancing mitochondrial respiration, NR supplementation may contribute to improved energy levels, enhanced physical performance, and overall vitality.
DNA Repair and Cellular Integrity:
Another compelling aspect of NR supplementation lies in its potential to support DNA repair mechanisms and maintain cellular integrity. NAD+ serves as a crucial cofactor for enzymes involved in DNA repair pathways, helping to safeguard against DNA damage and mutations. By replenishing NAD+ levels, NR supplements may enhance the body’s ability to repair damaged DNA, mitigate oxidative stress, and promote cellular longevity.
Cardiovascular Health:
Emerging research suggests that Nicotinamide Riboside supplementation may confer benefits for cardiovascular health and function. NAD+ plays a critical role in regulating vascular tone, endothelial function, and cardiovascular homeostasis. By promoting NAD+ synthesis, NR supplements may help support healthy blood flow, endothelial function, and cardiovascular resilience. Additionally, NR’s anti-inflammatory properties and ability to mitigate oxidative stress may further contribute to cardiovascular protection and overall heart health.
Metabolic Health and Weight Management:
Maintaining optimal metabolic health is essential for overall well-being and disease prevention. Nicotinamide Riboside supplements may offer promising implications for metabolic health and weight management by enhancing mitochondrial function, promoting energy expenditure, and optimizing metabolic efficiency. NR supplementation has been linked to improvements in insulin sensitivity, glucose metabolism, and lipid profiles, making it a potential adjunctive therapy for individuals seeking to support their metabolic health and achieve weight management goals.
Cognitive Function and Brain Health:
The brain, with its high energy demands and susceptibility to oxidative stress, stands to benefit from Nicotinamide Riboside supplementation. NAD+ plays a crucial role in neuronal health, synaptic plasticity, and cognitive function. By supporting NAD+ levels, NR supplements may help preserve cognitive function, enhance memory retention, and mitigate age-related cognitive decline. Additionally, NR’s neuroprotective properties and ability to modulate neuroinflammatory pathways hold promise for promoting brain health and resilience against neurodegenerative diseases.
Exercise Performance and Recovery:
For individuals seeking to optimize their athletic performance and recovery, Nicotinamide Riboside supplements may offer a valuable ally. NR supplementation has been shown to enhance mitochondrial biogenesis, improve muscle endurance, and facilitate faster recovery from exercise-induced fatigue. By bolstering cellular energy production and mitigating oxidative stress, NR supplements may help athletes and fitness enthusiasts maximize their performance potential, recover more efficiently, and sustain peak physical vitality.
Skin Health and Anti-Aging:
The skin, as the body’s largest organ, is constantly exposed to environmental stressors and oxidative damage. Nicotinamide Riboside supplementation may support skin health and anti-aging by promoting cellular repair mechanisms, enhancing collagen synthesis, and mitigating oxidative stress. NAD+ plays a critical role in DNA repair pathways within skin cells, helping to maintain skin integrity and resilience against photoaging and environmental aggressors. By replenishing NAD+ levels, NR supplements may contribute to a more youthful complexion, improved skin texture, and enhanced overall skin health.
Side-effects of using Nicotinamide Riboside Supplements
While Nicotinamide Riboside (NR) supplements hold promise for enhancing health and vitality, it’s important to acknowledge the potential for side effects and adverse reactions, particularly in certain individuals or under specific circumstances.
Gastrointestinal Disturbances: Some individuals may experience gastrointestinal discomfort or disturbances when first starting Nicotinamide Riboside supplementation. Symptoms such as nausea, abdominal cramping, diarrhea, or bloating may occur, especially at higher doses or in sensitive individuals. These side effects are often transient and may subside as the body adjusts to the supplement. Starting with a lower dosage and gradually increasing intake can help mitigate gastrointestinal discomfort.
Potential Interactions with Medications: Nicotinamide Riboside supplements may interact with certain medications, potentially altering their efficacy or increasing the risk of adverse effects. Individuals taking medications such as blood thinners, diabetes medications, or chemotherapy drugs should exercise caution and consult with a healthcare professional before starting NR supplementation. Additionally, individuals with pre-existing medical conditions or those taking other supplements should seek guidance from a healthcare provider to minimize the risk of interactions.
Allergic Reactions: In rare cases, individuals may experience allergic reactions to Nicotinamide Riboside supplements or other ingredients used in their formulation. Allergic reactions may manifest as skin rashes, itching, swelling, or difficulty breathing. If you experience any signs of an allergic reaction after taking NR supplements, discontinue use immediately and seek medical attention.
Impact on Blood Sugar Levels: Nicotinamide Riboside supplementation may affect blood sugar levels, particularly in individuals with diabetes or insulin resistance. While some studies suggest that NR may improve insulin sensitivity and glucose metabolism, others indicate that it may lower blood sugar levels, potentially leading to hypoglycemia in susceptible individuals. Individuals with diabetes should monitor their blood sugar levels closely when initiating NR supplementation and consult with a healthcare provider to adjust medication dosages as needed.
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Conclusion
In conclusion, Nicotinamide Riboside supplements present a fascinating avenue for those seeking to optimize their health and vitality. As we’ve explored throughout this article, NR supplements offer a promising array of potential benefits, ranging from supporting cellular energy production and mitochondrial function to promoting cardiovascular health, cognitive function, and metabolic resilience. With their ability to replenish NAD+ levels and activate key pathways involved in cellular repair and rejuvenation, NR supplements have garnered attention for their role in mitigating age-related decline and promoting longevity.
However, it’s essential to approach Nicotinamide Riboside supplementation with a balanced perspective, acknowledging both the potential benefits and the potential risks. While NR supplements are generally well-tolerated, some individuals may experience side effects such as gastrointestinal disturbances, interactions with medications, allergic reactions, or fluctuations in blood sugar levels. By staying informed, starting with conservative dosages, and seeking guidance from healthcare professionals, individuals can navigate the use of NR supplements safely and effectively.
Furthermore, it’s important to recognize that Nicotinamide Riboside supplementation is just one piece of the wellness puzzle. Optimal health and vitality encompass a holistic approach that includes regular physical activity, a balanced diet rich in nutrients, adequate sleep, stress management techniques, and meaningful social connections. NR supplements should complement, rather than replace, these foundational elements of a healthy lifestyle.
Stacy has been a registered dietitian since 2010, She is currently working as an author, and clinical dietitian at Zotezo. She has experience in various fields of nutrition including research, fitness, medical weight loss, long-term care, rehab, and bariatrics. She has also been contributing to various online entities since 2011 including Examiner.com, Livestrong, and Cdiabetes.com
