Introduction

The Best Alpha Lipoic Acid Supplements in USA have received much attention in recent years.

It’s a natural substance that acts as a powerful antioxidant in the body. Alpha-lipoic acid is produced naturally by your body, but it can also be found in several foods and nutritional supplements.

According to a recently conducted study, it plays a crucial role in weight loss, diabetes, and other health disorders.

There are a lot of theories that remain unconfirmed. But we are here with some proven benefits, a perfect buyer’s guide, and a list of top 7 best alpha-lipoic acid supplements in USA

Alpha Lipoic Acid Supplements in USA

Our pick of the 7 best alpha-lipoic acid supplements of 2024 in USA

Let's take a deep dive into these 7 best Alpha Lipoic Acid Supplements in USA

Best Overall Alpha Lipoic Acid Supplements in USA

Double Wood Supplements

A+

Zotezo review

The Alpha Lipoic Acid supplement by Double Wood offers a potent antioxidant solution for neuropathy and cardiovascular health, with the added benefits of being third-party tested, manufactured in the USA, and vegan safe. However, potential cons include a sooner-than-expected expiration date and the presence of rice in some products, which may pose a concern for individuals with rice allergies.

Product details

  • 600mg of Alpha Lipoic Acid per serving

  • 60 capsules per bottle

  • Third-party tested

  • Manufactured in the USA

  • Vegan safe

  • Potent antioxidant for neuropathy and cardiovascular health

Benefits of Double Wood ALA 600mg Capsules

  • Third Party Tested

  • Manufactured in The USA

  • Vegan Safe

  • Potent Antioxidant for Neuropathy and Cardiovascular Health

Drawbacks

  • Expiration date of 12/2024 may be sooner than expected

  • Some Double Wood products contain rice, which may be an issue for individuals with rice allergies

NOW Sports - Nutrition and Wellness

A+

Zotezo review

The NOW Supplements Alpha Lipoic Acid 600 mg with Grape Seed Extract & Bioperine® offers a cost-effective and easy-to-take Extra Strength formula. However, some users may find the capsules too large, and a few customers reported no noticeable effects after taking the supplement.

Product details

  • 600 mg of Alpha Lipoic Acid

  • Contains Grape Seed Extract

  • Includes Bioperine® for enhanced absorption

  • Extra Strength formula

  • 120 Veg Capsules

  • Kosher, Dairy Free, Egg Free, Gluten Free, Nut Free, Soy Free, Vegan/Vegetarian

Benefits of NOW Alpha Lipoic Acid 600mg

  • Cost-effective

  • Easy to take

  • Extra Strength formula

Weaknesses

  • Some users may find the capsules too large

  • A few customers reported no noticeable effects after taking the supplement

A+

Zotezo review

The THORNE Alpha-Lipoic Acid supplement offers comprehensive support for liver detox, antioxidant protection, and nerve health. While it may come at a higher price point and not deliver noticeable effects for everyone, its quality ingredients and benefits make it a solid choice for those seeking these specific health benefits.

Product details

  • Nerve protective effects

  • Liver health support

  • Mental sharpness maintenance

  • Ingredients sourced from purest sources worldwide

  • Natural flavors, colors, preservatives, and sweeteners

  • Contains Thorne's high-quality formula

Benefits of THORNE Alpha-Lipoic Acid 300mg &...

  • Supports liver detox

  • Provides antioxidant support

  • Promotes nerve health

Disadvantages

  • Higher price compared to some alternatives

  • May not provide noticeable effects for everyone

A+

Zotezo review

The Jarrow Formulas Alpha Lipoic Sustain with Biotin is a comprehensive dietary supplement that offers antioxidant, cellular energy production, and normal glucose metabolism support. While some users may find the vanilla taste overwhelming and the product may not be widely recognized, it is a beneficial option for those seeking these specific health benefits.

Product details

  • Contains 300 mg of Alpha Lipoic Acid

  • Includes Biotin

  • Supports antioxidant function

  • Supports cellular energy production

  • Supports normal glucose metabolism

Benefits of Jarrow Alpha Lipoic Sustain with...

  • Antioxidant support

  • Cellular energy production

  • Normal glucose metabolism support

  • Contains biotin for additional benefits

Negatives

  • Some users may find the vanilla taste of the tablets overpowering

  • The supplement may not be well-known or recognized by all healthcare professionals

B+

Zotezo review

The Sundown Alpha Lipoic Acid 600mg dietary supplement is a high-quality product that supports antioxidant health, recommended by physicians, competitively priced, and well packaged. However, users may experience discomfort due to the large capsules and potential for reflux or heartburn.

Product details

  • Contains 600mg of Alpha Lipoic Acid

  • Supports Antioxidant Health

  • Helps turn glucose into cellular energy

  • Comes in a 60 Capsule dietary supplement bottle

Benefits of Sundown Alpha Lipoic Acid 600mg ...

  • Supports antioxidant health

  • High quality product

  • Recommended by a primary physician

  • Well packaged

  • Competitively priced

Cons

  • Large capsules

  • Potential for reflux or heartburn

B+

Zotezo review

The Alpha Lipoic Acid 600mg supplement by Horbaach offers a premium form of ALA with 600mg per serving and 999mcg of Biotin, but some users may find the large pills difficult to swallow and effectiveness improved when taken with food.

Product details

  • Premium form of ALA

  • 600 mg of ALA per serving

  • 999 mcg of Biotin per serving

  • Quick-release capsules

Benefits of Horbaach Alpha Lipoic Acid 600mg...

  • Premium form of ALA

  • Contains 600mg of ALA per serving

  • Includes 999mcg of Biotin per serving

Drawbacks

  • Large pills can be difficult to swallow

  • May be more effective when taken with food

B+

Zotezo review

The Nutricost Alpha Lipoic Acid 600mg capsules offer a convenient way to supplement with a high dosage of Alpha Lipoic Acid in a vegetarian, gluten-free, non-GMO formula. However, some users may experience lingering numbness in toes, and not all healthcare professionals may be fully informed about its benefits.

Product details

  • 240 capsules per bottle

  • 600mg of Alpha Lipoic Acid per serving

  • Vegetarian capsules

  • Non-GMO

  • Gluten-free

Benefits of Nutricost Alpha Lipoic Acid 240 ...

  • Easy to swallow capsules

  • Gluten-free

  • Vegetarian capsules

  • Soy-free

  • Non-GMO

Weaknesses

  • Some users may experience lingering numbness in toes

  • Not all doctors may be fully knowledgeable about the benefits of the product

Tips for choosing the right alpha-lipoic acid supplements for you

Here are a few vital factors to consider before buying the supplement.

Certified

Make sure your supplement is third-party verified. Supplements that have been third-party tested are taken to a lab for testing. It ensures that they contain what they claim and do not contain high-risk, common contaminants. ConsumerLabs, NSF, and USP are three third-party certifications you can trust.

Form

The Best Alpha Lipoic Acid supplements in USA are available in capsule and powder form. It is your choice to select whichever you feel comfortable with. However, powder form is easy to intake.

Capsule size

Swallowing large ALA supplement capsules can be challenging. If you know this will be a problem for you, determine the size of the capsules before you buy them. To know what you are receiving before you buy, check the capsule size mentioned by manufacturers.

Transparency

Choose a brand that offers pure transparency for its product. The label should contain information about ingredients, source, packaging, etc. Do not trust any brand that hides the ingredients list. In addition, the brand should have valid answers to any question regarding the product. 

Ingredients

Check the ingredients when purchasing the Best Alpha Lipoic Acid supplement in USA. The supplement should be pure and not contain any additives. It should not contain any ingredients you are allergic to. Look for a capsule that has maximum ALA.

Expiry date 

Check the supplement’s expiration date and ensure it has a long shelf life. The shelf life should be up to 18 months after it was manufactured. Do not buy supplements that are going to expire.

Product review

Look for a product review when buying ALA supplements online. This provides first-hand and extensive information regarding alpha-lipoic acid supplements from real-world users.

Products listed here are carefully reviewed and tested by our expert authors and reviewers. If you buy through links on this page, we may earn a small commission. Here’s our editorial process.

How we reviewed these products

Benefits of using alpha-lipoic acid supplements

ALA supplements offer various health benefits. Here are some of them:

Antioxidant

ALA has been shown in various studies to improve the body’s antioxidant resources in situations like HIV, liver illness, obesity-related cardiovascular disease, diabetes, and exercise-induced muscle damage.

Treating Diabetes

ALA has been approved in several countries as part of a diabetic treatment plan because it appears to have potential benefits in the prevention of diabetes. It possesses insulin-mimetic activity that helps with glucose absorption and management. In patients with type 2 diabetes, particularly overweight adults, ALA decreases blood glucose and increases insulin sensitivity.

Weight loss

ALA is the ideal supplement to a weight-loss regimen, but it won’t help you lose weight by itself. It increases glucose and fat metabolism, meaning that more sugars and fats in foods are broken down and utilized for energy rather than being stored as fat. Lipoic acid prevents Chemerin, a chemical linked to obesity and metabolic syndrome. It could be one of the ways lipoic acid can help with obesity and diabetes.

Inflammation

A study examined the effects of ALA and irbesartan (a drug used to treat high blood pressure, diabetic neuropathy, and kidney disease) on metabolic syndrome. The findings imply that giving ALA and irbesartan to those with metabolic syndrome improves endothelial function and inflammation.

Diabetes neuropathy

It is a form of nerve pain associated with diabetes. It occurs when high blood sugar levels damage nerve fibers. The legs and feet are the most commonly affected areas. The research investigates the efficacy of ALA for treating diabetic neuropathy and implies that alpha-lipoic acid (ALA) is a viable treatment option for diabetic neuropathy.

Treats migraine

Migraines are associated with oxidative stress and mitochondrial dysfunction. The best alpha-lipoic acid supplements in USA are beneficial in both cases. Topiramate, a migraine medicine, is more effective when used with lipoic acid. In terms of lowering the frequency and duration of migraines, the combination of lipoic acid and topiramate was much more beneficial than either medicine alone.

Blood pressure

The effects of ALA on High blood pressure have been studied in various clinical investigations. However, the results are contradictory. More research is required.

Pain management

Although lipoic acid is not as effective as typical pain medications, it can lower the number of pharmaceutical drugs required to control pain. However, much more research is needed to determine its significance in pain treatment.

Skin health

The Best Alpha Lipoic Acid Supplements in USA help accelerate wound healing in patients with chronic wounds and aged patients. When administered directly to the skin, ALA enhances skin thickness and reduces roughness and UV damage. In addition, according to some research, topical lipoic acid can restore skin smoke-induced skin damage.

Side-effects of using Alpha Lipoic Acid Supplements

Alpha-lipoic acid supplements may be considered safe for most adults when taken for up to four years. It is usually tolerated well. It rarely shows any side effects. The most common side effects are nausea and rashes. You may also suffer from:

  • Headache
  • Fatigue
  • Diarrhea
  • Muscle cramps
  • Tingling “pins and needles” sensation
  • Difficulty breathing
  • Faintness
  • Rapid heartbeat

If you suffer any of the following effects, you should stop taking ALA and seek medical help right away.

Precautions

Do not take different kinds of alpha-lipoic acid (tablets and capsules) simultaneously without consulting a doctor. When you combine multiple formulations, you run the danger of overdosing. Avoid taking ALA supplements;

Under certain medication:

  • Insulin or any other medicine for diabetes
  • Medicines to treat an underactive thyroid
  • cancer medicines
  • Anticoagulant / Anti-platelet drugs

Under certain conditions:

  • ALA supplements are safe for pregnant and breastfeeding women. They should always consider taking them under medical guidance. 
  • There are no clear studies about ALA supplements’ safety for children. Avoid giving children such.
  • Stop taking ALA supplements two weeks before any surgery.
  • suffering from any liver disease
  • If you have thiamine deficiency
  • If you consume too much alcohol

Who should use alpha-lipoic acid supplements

Alpha-lipoic acid may help people with prolonged period of diabetes, It helps lowering blood sugar levels, according to several studies. People with diabetic peripheral neuropathy that causes pain, burning, itching, tingling, and numbness in their limbs and legs due to nerve loss, may benefit from it because of its capacity to eliminate free radicals.

Adults can take 600-1800 mg of alpha-lipoic acid daily by oral for up to 6 months. It is recommended to take alpha-lipoic supplements on an empty stomach Because certain foods can reduce the acid’s absorption.

To know what dose is best for a particular disease, speak with a healthcare provider.

How to consume Alpha Lipoic Acid Supplements

A range of foods including red meat, potatoes, broccoli, beets, carrots, and spinach generally contain alpha-lipoic acid. It can be found in supplements as well. Alpha-lipoic acid may protect the brain and be beneficial in some liver illnesses since it appears to function as an antioxidant. The best way to consume alfa lipoic acid on an empty stomach and you will get the maximum benefits if continue for 6 months.

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Brand stories

Frequently asked questions on alpha-lipoic acid supplements

1. What is the natural source of ALA?

2. What if I miss my dose?

3. What if I overdose?

4. Does ALA help to sleep?

5. What is the chance of ALA deficiency?

6. Who Cannot consume alpha-lipoic acid?

7. What is the richest source of alpha-lipoic acid?

Expert reviews you can rely upon

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Expert Advisory

Conclusion

Everyone wants to live a healthy lifestyle, and everyone should begin with small measures to achieve their ultimate objective of excellent health. Purchasing the best alpha-lipoic acid supplements in USA is a great way to start living a healthier lifestyle.

We believe that our in-depth alpha-lipoic acid evaluations and the complete buyer’s guide help you make an informed decision. Therefore, make sure you get your doctor’s approval before selecting any particular product.

Did you find this article interesting? Were these products on your checklist as well? 

Do keep us posted in the comments below and share it with your friends, families and beloved. Also, don’t forget to mention the best Alpha Lipoic Acid supplements in USA that you pick up from the most reliable e-commerce store. 

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Dt. Stacy Gulbin

RD, M.Ed., MS

Dietitian verified

Stacy has been a registered dietitian since 2010, She is currently working as an author, and clinical dietitian at Zotezo. She has experience in various fields of nutrition including research, fitness, medical weight loss, long-term care, rehab, and bariatrics. She has also been contributing to various online entities since 2011 including Examiner.com, Livestrong, and Cdiabetes.com