Introduction

The lion’s mane mushroom (Hericium erinaceus) has a long history of use in traditional Chinese medicine. It is believed to have medicinal properties and was traditionally used to improve cognitive function, boost overall well-being, and support nerve function. In recent years, lion’s mane supplements have become increasingly popular globally as a natural way to improve brain health and cognitive function. This is partly due to the growing body of research suggesting that compounds in the mushroom may have neuroprotective effects and may support the growth and repair of nerve cells. These dietary supplements have a rich quantity of lion’s mane mushroom extract. They are often marketed as natural ways to improve brain health, boost focus and concentration, and support nerve function. This blog will share all the necessary information about the 6 best lion’s mane supplements in USA.

lion's mane supplements in USA

Our pick of the 6 best lion's mane mushroom extract of 2024 in USA

Let's take a deep dive into these 6 best lion's mane supplements in USA

Best Overall lion's mane supplements in USA

Real Mushrooms

A+

Zotezo review

The Real Mushrooms Lion’s Mane Capsules offer an affordable and high-quality organic Lion’s Mane mushroom extract that supports cognitive function and overall well-being. While some users may question its effectiveness and find the dosage high, it has shown positive impacts on memory and cognitive function for many.

Product details

  • Made with hand-picked Lion's Mane mushroom extract

  • Supports cognitive function

  • Supports overall well-being

  • Organic mushroom extract

  • Vegan

  • Contains 300 capsules

Benefits of Lion’s Mane Capsules by Re...

  • Affordable compared to competitors

  • Family-owned business with a passion for high-quality standards

  • Positive impact on memory and cognitive function

Drawbacks

  • Disbelief about effectiveness for some users

  • Some users may find the recommended dosage too high

B+

Zotezo review

The Genius Lions Mane Supplement Capsules are an organic nootropic supplement offering 1200mg per serving, promoting enhanced focus, improved cognition, better memory, increased clarity, and boosted mental acuity. While the product’s natural formulation supports the immune system, potential drawbacks include the lack of scientific quantification of effects and individual variations in experiences.

Product details

  • Organic Nootropic Supplement

  • 1200mg per Serving

  • Helps Increase Focus

  • Helps Improve Cognition

  • Aids Memory

  • Enhances Clarity

Benefits of Lions Mane Nootropic Capsules &#...

  • Enhanced focus

  • Improved cognition

  • Better memory

  • Increased clarity

  • Boosts mental acuity

  • Supports immune system

  • Natural and clean formulation

Weaknesses

  • Lack of scientific quantification of effects

  • Individual experiences may vary

Double Wood Supplements

B+

Zotezo review

The Lions Mane Supplement Mushroom Capsules by Double Wood offer a fresh, USA-grown product that supports brain function and immune health over a two-month supply. While some users reported dosage confusion and gradual results, many found it to work relatively well for brain support and neurogenesis.

Product details

  • Two-month supply with 120 capsules

  • Supports neurogenesis

  • Supports brain cell growth

  • Third-party tested

  • Grown and manufactured in the USA

Benefits of Double Wood Lions Mane Capsules

  • Fresh product

  • Works relatively well

  • Two-month supply

  • Supports brain function

  • Supports immune health

  • Grown and manufactured in the USA

Disadvantages

  • Dosage confusion reported by some users

  • Results may be gradual and not immediate

B+

Zotezo review

Horbaach’s Lion’s Mane Mushroom Extract offers a high-potency dose of 4200mg per serving in a convenient vegetarian, non-GMO, and gluten-free capsule form. While delivering improved cognitive function and mental clarity, it provides good value for money, although some users may find the capsules too large to swallow and those with mushroom allergies should exercise caution.

Product details

  • Lion's Mane Mushroom Extract

  • 4200mg per serving

  • 120 Capsules

  • Vegetarian

  • Non-GMO

  • Gluten Free

Benefits of Horbaach Lion’s Mane Mushr...

  • High potency with 4200mg per serving

  • Vegetarian

  • Non-GMO

  • Gluten-free

  • Improved cognitive function and mental clarity

  • Convenient capsule form

  • Good value for money

Negatives

  • Some users may find the capsules too large to swallow

  • May not be suitable for those with allergies to mushrooms

NOW Sports - Nutrition and Wellness

B

Zotezo review

The NOW Supplements Lion’s Mane 500 mg capsules are a high-quality product made with organic Lion’s Mane Mushrooms that support neuronal health. While some users may experience subtle effects and find it unsuitable, it is still a good option for those looking to enhance general well-being.

Product details

  • Super Mushroom with history of traditional use

  • Non-GMO Project Verified

  • Supports general well-being

  • Supports neuronal health

  • Made with organic Lion's Mane Mushrooms

  • Contains 60 Veg Capsules

Benefits of NOW Lion’s Mane 500 mg Cap...

  • Supports neuronal health

  • Made with organic Lion's Mane Mushrooms

  • Non-GMO Project Verified

Cons

  • Subtle effects

  • May not be suitable for everyone

B

Zotezo review

The Host Defense Lion’s Mane Capsules are a trusted, natural mushroom supplement that effectively promotes mental clarity, enhances focus, and supports memory. While the unflavored nature of the capsules may not suit all taste preferences, their ease of incorporation into a daily routine makes them a convenient choice for those seeking cognitive and immune support.

Product details

  • Promotes mental clarity

  • Enhances focus

  • Supports memory

  • Boosts natural immunity

  • Provides cerebral and nervous system support

  • Optimizes immune system

Benefits of Host Defense Lion’s Mane C...

  • Promotes mental clarity

  • Enhances focus

  • Supports memory

  • Easy incorporation into daily routine

  • Natural and mushroom-derived

  • Trusted brand with quality assurance

  • Unflavored simplicity

Drawbacks

  • Potential concerns about taste preferences due to unflavored nature of the capsules

  • Some users may find the capsules challenging to swallow

Tips for choosing the right lion's mane mushroom extract for you

When buying a lion’s mane supplement, there are a few things to keep in mind to ensure you are getting a high-quality product:

Check the source:

Make sure the lion’s mane supplement you are considering is made from mushrooms grown in a clean, controlled environment to avoid contamination.

Look for third-party testing:

Choose a product independently tested for purity and potency by a reputable third-party lab.

Check the dosage:

The recommended dosage for lion’s mane supplements can vary depending on the product, so be sure to read the label and follow the manufacturer’s instructions.

Consider the form:

Lion’s mane supplements are available in various forms, including capsules, powders, and teas. Choose the form that best suits your needs and preferences.

Research the brand:

Look for brands with a reputation for producing high-quality supplements and good customer service.

Consult a healthcare professional:

If you have any health concerns or are taking any medications, it’s always a good idea to consult a healthcare professional before taking a new supplement.

However, you should also be aware of the ingredients in lion’s mane supplements. The mushroom is usually dried and then ground into a powder before being used to make supplements. The extract may be standardized to a specific concentration of active compounds, such as polysaccharides or hericystin.

Some of the key ingredients present in lion’s mane supplements include:

  1. Polysaccharides are complex sugars shown to have immune-boosting and anti-inflammatory effects.
  2. Hericystin is a compound called cyathane diterpene, shown to have neuroprotective properties.
  3. Ergothioneine is an antioxidant with anti-inflammatory properties that may help protect against cell damage.
  4. Beta-glucans is a complex carbohydrate that has been shown to have immune-boosting effects.
  5. Triterpenoids are a class of compounds shown to have anti-inflammatory and antioxidant properties.

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Benefits of using lion's mane mushroom extract

Lion’s mane mushroom supplements are believed to have several potential health benefits, although more research is needed to confirm their effectiveness. Some of the potential benefits of lion’s mane supplements include:

 

benefits of lion's mane supplements

 

Improving cognitive function:

Some studies have suggested that compounds in lion’s mane mushrooms may have neuroprotective effects and may support the growth and repair of nerve cells, which can help improve cognitive function, concentration, and memory.

Reducing anxiety and depression:

Compounds in lion’s mane mushrooms may also support the growth and repair of nerve cells, which can help to improve nerve function and overall cognitive function.

Supporting nerve function

Lion’s mane mushroom supplements may support nerve function by providing the body with a rich source of antioxidants, which can help to protect the nerves from damage and promote repair. Compounds in lion’s mane mushrooms like hericystin and polysaccharides may also support the growth and repair of nerve cells, which can help to improve nerve function and overall cognitive function.

Boosting the immune system:

Lion’s mane mushroom supplements also contain beta-glucans, complex carbohydrates that have been shown to have immune-boosting effects. They can stimulate the immune system by activating white blood cells, such as macrophages and natural killer cells, which help to fight off infections and diseases.

Anti-inflammatory effects:

Lion’s mane supplements may have anti-inflammatory effects, which may help reduce inflammation throughout the body and relieve people with conditions such as osteoarthritis and rheumatoid arthritis.

 

Side-effects of using lion's mane supplements

Lion’s mane mushroom supplements are generally considered safe when taken as directed. However, as with any supplement, there is a risk of side effects, particularly when taken in high doses or combined with certain medications. Some possible side effects of lion’s mane mushroom supplements include:

Digestive issues:

Some people may experience mild stomach upset, nausea, or diarrhea when taking lion’s mane mushroom supplements.

Allergic reactions:

In rare cases, people may be allergic to lion’s mane mushroom extract, which can cause hives, itching, or difficulty breathing.

Interaction with medication:

Lion’s mane mushroom supplements may interact with certain medications, such as blood thinners, so you must consult with a healthcare professional before taking lion’s mane mushroom supplements if you take any medications.

Pregnant or breastfeeding:

Pregnant or breastfeeding women should avoid taking lion’s mane mushroom extract supplements without consulting with a healthcare professional.

 

The recommended dosage of lion’s mane mushroom extract supplements can vary depending on the product and the form of the supplement, as well as the individual’s specific needs and health condition. Typically, the recommended dosage for these supplements is between 500-3000 mg daily, taken in divided doses. For example, a dosage of 1000mg per day would be taken as two doses of 500mg each. Some products may recommend a higher or lower dosage, so following the manufacturer’s instructions is essential.

 

How to consume lion's mane supplements

There are several different types of lion’s mane mushroom supplements available on the market, each with its unique characteristics. These include:

Capsules:

These are the most common form of lion’s mane supplement and are easy to take. They typically contain a powdered mushroom extract encapsulated in a vegetable-based capsule.

Powders:

These supplements are made by drying and grinding the mushroom into a fine powder. One of the benefits of using lion’s mane powder is that it can be easily added to food and drinks, making it a convenient way to consume the mushroom. Additionally, lion’s mane powder can be used in cooking, adding the mushroom’s flavor to your dishes.

Teas:

Lion’s mane mushroom tea is a dietary supplement made from the dried fruiting body of the lion’s mane mushroom (Hericium erinaceus). The tea can be prepared by steeping dried lion’s mane mushrooms in hot water, just like any other herbal tea.

Tinctures:

Lion’s mane mushroom tinctures are liquid extracts of the mushroom that are taken in droplet form. They are typically made by steeping dried lion’s mane mushrooms in a high-proof alcohol or glycerin solution to extract the active compounds. The tincture is usually consumed by placing a few drops under the tongue or adding them to a drink.

Tinctures can be a convenient way to consume lion’s mane mushrooms, as they are easy to take on the go and can be added to drinks or food. They also can be consumed sublingually; this way, the active compounds can be absorbed directly into the bloodstream for a quicker effect.

Tablets:

These dietary supplements contain extracts of the lion’s mane mushroom in a compressed form. They can be easily swallowed, which is a convenient way to consume mushrooms. The extract may be standardized to a specific concentration of active compounds, such as polysaccharides or hericystin.

It’s worth noting that the effectiveness of any supplement can vary depending on the person and the dosage. More research is needed to confirm the effectiveness of Lion’s Mane supplements, so it’s always important to consult with a medical expert before taking any supplement.

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Frequently asked questions on lion's mane mushroom extract

1. What are lion's mane supplements?

2. What are the potential benefits of lion's mane supplements?

3. What is the recommended dosage of lion's mane mushroom extract?

4. Who can use lion's mane supplements?

5. Are there any side effects of lion's mane supplements?

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Conclusion

 

Available in various forms such as capsules, powders, teas, tinctures, and tablets, lion’s mane supplements are one of the best dietary supplements that contain lion’s mane mushroom extracts. These supplements have remarkable medicinal properties due to the mushroom extract’s presence. Lion’s mane supplements have properties that improve cognitive function, reduce anxiety and depression, support nerve function, boost the immune system, and reduce inflammation. The dosage depends on people and how intense is their medical condition. These supplements are one of the biggest blessings of nature as they enhance health status.

 

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Dr. Heather Smith

MD, FRCP

Medical Practitioner verified

By day I’m a critical care physician and medical leader. By night I’m the mom of 2 chaotic, wonderful boys. Somewhere in the middle of all that, I’m building a skincare brand and trying to save the world from plastic waste.